ea0009p124 | Endocrine tumours and neoplasia | BES2005
McGowan B
, Stanley S
, Smith K
, White N
, Connolly M
, Gardiner J
, Ghatei M
, Bloom S
Relaxin-3 (INSL-7) is a recently discovered member of the insulin superfamily, a group of structurally related hormones whose precursors have a domain arrangement similar to that of pro-insulin. Relaxin-3 mRNA is expressed in the nucleus incertus of the brainstem which has projections to the hypothalamus, an area important in appetite regulation. Relaxin-3 binds with high affinity to the recently discovered previously orphan G-protein-coupled receptor, GPCR135, which is expres...